Question 1

What is tirzepatide?

Accepted Answer

Tirzepatide is a dual GLP-1 and GIP receptor agonist. The brand-name versions are Mounjaro® (FDA-approved for type 2 diabetes) and Zepbound® (FDA-approved for chronic weight management). In clinical trials of the FDA-approved brand product, tirzepatide produced significant weight loss results. Compounded tirzepatide is custom-prepared by a licensed compounding pharmacy and is not FDA-approved or evaluated for equivalence to brand products.

Question 2

How is tirzepatide different from semaglutide?

Accepted Answer

While semaglutide targets only the GLP-1 receptor, tirzepatide activates both GLP-1 and GIP receptors. A dual mechanism of action. This dual targeting has been shown to produce greater weight loss in head-to-head trials: an average of 22.5% body weight loss with tirzepatide vs. 15-17% with semaglutide. Tirzepatide may also have fewer GI side effects for some patients.

Question 3

How much weight can I expect to lose?

Accepted Answer

The SURMOUNT-1 trial of brand-name tirzepatide (Zepbound®) showed that participants on the highest dose experienced an average reduction of 22.5% of their body weight over 72 weeks. These results are from clinical trials of the FDA-approved brand product. Compounded versions are not FDA-approved and have not been independently studied. Individual results vary significantly based on starting weight, dosage, diet, exercise, and individual response. There are no guarantees of weight loss.

Question 4

How do I take tirzepatide?

Accepted Answer

Tirzepatide is a once-weekly injection administered just under the skin, typically in the abdomen, thigh, or upper arm. Your provider will start you on a low dose (2.5mg) and gradually increase every 4 weeks based on your response and tolerance. The full dose escalation takes about 20 weeks.

Question 5

What are the common side effects?

Accepted Answer

The most common side effects are mild to moderate nausea, decreased appetite, and occasional diarrhea. Primarily during the first few weeks and dose increases. Many patients report that tirzepatide has fewer GI side effects than semaglutide. Our gradual dose-escalation protocol minimizes these effects, and your care team is available 24/7.

Question 6

Why is tirzepatide more expensive than semaglutide?

Accepted Answer

Tirzepatide is a newer, more complex molecule with a dual mechanism of action that generally produces greater weight loss. The compounding process is also more involved. However, at $249/mo through Puri, compounded tirzepatide is still a fraction of the brand-name cost (Mounjaro® lists at $1,000+/mo without insurance).

Compounded tirzepatide. Physician prescribed.

How tirzepatide works

Dual receptor activation

Superior appetite control

Enhanced metabolic function

Tirzepatide programs

Compounded Tirzepatide Injection

Brand Zepbound® Injection

How it works

Complete an Assessment

Clinician Review

Pharmacy Delivery

Tirzepatide FAQ

Care that puts you first.